本院专任教授

近年学术成果（#并列第一作者；*通讯作者）

1.Jie Ma , Wei Yang, Fu-Ming Chen , Qian He , Hua-Lin Ma , Cong-Hui Li , Min-Li Liang, Jia-Qi Zhong , Xin-Zhou Zhang , Fu-Rong Li*. IRF8 and RUNX1 cooperatively regulate the senescence and damage of urine-derived renal progenitor cells by upregulating LINC01806. Biochemical Pharmacology 2025,240: 117068

2.Haojie Yan，Qian He，Yubiao Gao，Xiaomei He，Haitao Luo，Lijuan Shao，Jun Dong*, Furong Li*.SLC4A7 suppresses lung adenocarcinoma oncogenesis by reducing lactate transport and protein lactylation.International Journal of Oncology.2025,33:66.

3.Lin Ding, Chih-Jung Chang, Min-Li Liang, Kang-Mei Dong, and Fu-Rong Li*.Plant-Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics.Adv. Therap. 2024, 2400256. (IF: 3.7; Q2).

4.Fuming Chen, Jing Wang, Jie Ma, Li Song, Haojie Yan, Feng Wang, Zhengrong Yang, Furong Li*.Novel DNA Biosensing Platform for Detecting HIV Integrase for Highly Sensitive and Quantitative HIV Detection, Diagnosis, and Therapeutic Monitoring. ACS Omega. 2024; 9(23): 25042-25053. (IF: 4.132; Q2).

5.Hao-Jie Yan, Sheng-Cheng Lin, Shao-Hang Xu, Yu-Biao Gao, Bao-Jin Zhou, Ruo Zhou, Fu-Ming Chen, Fu-Rong Li*.Proteomic analysis reveals LRPAP1 as a key player in the micropapillary pattern metastasis of lung adenocarcinoma.Heliyon. 2023;10(1):e23913. (IF: 4.0; Q1).

6.Yan Shi, Shang Wang, Dewu Liu, Zhengguang Wang , Yihan Zhu, Jun Li, Kui Xu, Furong Li*, Huicai Wen* and Ronghua Yang.Exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells facilitates diabetic wound healing by restoring keratinocyte autophagy. Burns & Trauma, 2024, 12, tkad058. (IF: 6.3; Q1).

7.Qian He，Shaohang Xu，Fei He，Zubiao Wu，Fujian Wu，Ruo Zhou ，Baojin Zhou，Furong Li*，Xiaofei Yang.*Combined Proteomic and Phosphoproteomic Characterization of the Molecular Regulators and Functional Modules During Pancreatic Progenitor Cell Development.J. Proteome Res. 2024, 23(1):40–51.

8.Luo HT, He Q, Yang W, He F, Dong J, Hu CF, Yang XF, Li N, Li FR*. Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors. Stem Cell Res Ther 2023;14(1):38. (IF: 7.5; Q1).

9.Fuming Chen, Weilin Lu, Lin Din, Jing Wang, Fu-Rong Li*. A novel RCA-based DNA sensor system for specific and quantitative detection of Klebsiella pneumonia. Microchemical Journal,2023,196:109584.(IF:4.80; Q1).

10.Qian He, Shaohang Xu,Fei He,Zubiao Wu,Fujian Wu,Ruo Zhou,Baojin Zhou*,Furong Li*, Xiaofei Yang*.Combined Proteomic and Phosphoproteomic Characterization of the Molecular Regulators and Functional Modules During Pancreatic Progenitor Cell Development.J. Proteome Res. 2023,(IF:4.421; Q1).

11.HaiTao Luo, Qian He, Wei Yang, Fei He， Jun Dong , ChaoFeng Hu , XiaoFei Yang, Ning Li and FuRong Li*.Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC diferentiation into pancreatic progenitors. Stem Cell Research & Therapy 2023;14:38.(IF:7.50; Q1).

12.Lin Ding,Minli Liang,Yuanyuan Li,Mei Zeng.Meiting Liu,Wei Ma,Fuming Chen,Chenchen Li,Rui L Reis,Fu-Rong Li*,Yanli Wang*.Zinc-Organometallic Framework Vaccine Controlled -Release Zn2+ Regulates Tumor Extracellular Matrix Degradation Potentiate Efficacy of Immunotherapy. Advance Science 2023;e2302967.(IF:15.100; Q1).

13. Meihua Gong , Fei Yan , Li Yu and Furong Li*.A dopamine-methacrylated hyaluronic acid hydrogel as an effective carrier for stem cells in skin regeneration therapy . Cell Death Dis. 2022;13(8):738. [IF=9.685] Q1

14.Lin Ding, Minli Liang, Chenchen Li, Xinting Ji, Junfeng Zhang, Weifen Xie , Rui L Reis, Fu-Rong Li* , Shuo Gu*, Yanli Wang* .Design Strategies of Tumor-Targeted Delivery Systems Based on 2D Nanomaterials.2Small Methods.2022;e2200853.[IF15.367] Q1

15.Hai-Bo Huang, Hai-Tao Luo, Na-Na Wei, Miao-Ling Liu, Fei He, Wei Yang, Jun Dong, Xiao-Fei Yang, Fu-Rong Li*.Integrative analysis reveals a lineage-specific circular RNA landscape for adipo-osteogenesis of human mesenchymal stem cells.Stem Cell Res Ther. 2022;13(1):106. [IF=8.079] Q1

16.Yan Shi , Shang Wang, Weiwei Zhang, Yihan Zhu, Zhiqiang Fan, Yuesheng Huang, Furong Li*, Ronghua Yang*.Bone marrow mesenchymal stem cells facilitate diabetic wound healing through the restoration of epidermal cell autophagy via the HIF-1α/TGF-β1/SMAD pathway.Stem Cell Res Ther. 2022;13(1):314. [IF=8.079] Q1

17.Wei Yang ,Yong Liang ,Yuanyuan Zheng ,Haitao Luo ,Xiaofei Yang ,and Furong Li*.Identification of Novel Multi-Omics Expression Landscapes and Meta-Analysis of Landscape-Based Competitive Endogenous RNA Networks in ALDH+ Lung Adenocarcinoma Stem Cells. BioMed Research International.2022:9545609. [IF=3.246] Q3

18.Haitao Luo,Dechao Bu,Lijuan Shao,Yang Li,Liang Sun,Ce Wang,Jing Wang,Wei Yang,Xiaofei Yang,Jun Dong,Yi Zhao,Furong Li*.Single-cell Long Non-coding RNA Landscape of T Cells in Human Cancer Immunity. Genomics, Proteomics & Bioinformatics. 2021;S1672- 0229(21) 00155-8. [IF7.6] Q1

19.Wang C, Chen S, Wu YJ,WU D, Wang JB, Li FR*.The combination therapy with EpCAM/CD3 BsAb and MUC-1/CD3 BsAb elicited antitumor immunity by T-cell adoptive immunotherapy in lung cancer. International Journal of Medical Sciences.2021;18 (15): 3380- 3388.[IF=3.738] Q1

20.Song L, Du NC, Luo HT, Li FR*.Screening and survival analysis of melanoma immunodrug response-related genes and the function of magnetic nanoparticles in gene extraction. Materials Express.2021;1306-1312.[IF=1.65] Q3

21.Shao LJ, He Q. Wang JB. He F, Yang XF*& Li FR*.MicroRNA-326 attenuates immune escape and prevents metastasis in lung adenocarcinoma by targeting PD-L1 and B7-H3.Cell Death Discovery.2021;7(1):145.[IF=5.241] Q2

22.Hai-Tao Luo，Yang Li, Rui-Jun Tian, Yuan-Yuan Zheng, Jun Tang, Li-Juan Shao and Fu-Rong Li*. Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells.NPJ Genom Med. 2021;6(1):48. [IF=8.617] Q1

23.Yang XF, Wu FJ, Zhong JQ, Li FR*.Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5A.Stem Cell Res.2021;51:102194. [IF=2.02] Q4

24.Qian He , Zubiao Wu, Wei Yang, Doukou Jiang, Chaofeng Hu, Xiaofei Yang, Ning Li and Furong Li*.IFI16 promotes human embryonic stem cell trilineage specification through interaction with p53.npj Regenerative Medicine.2020;5:18. [IF=14.4039]

25.Ning Li,Doukou Jiang1,Qian He, Fei He, Yang Li, Chunyan Deng and Furong Li*.microRNA-181c -5p promotes the formation of insulin-producing cells from human induced pluripotent stem cells by targeting smad7 and TGIF2. Cell Death and Disease 2020；11:462[IF=7.1089]

26.Yang XF, Zhou SY, Wang C, Huang W, Li N, He F, Li FR*. Inhibition of LSD1 promotes the differentiation of human induced pluripotent stem cells into insulin-producing cells. Stem Cell Res Ther. 2020;11(1):185. [IF=8.079]

27.He F, Li N, Huang HB, Wang JB, Yang XF, Wang HD, Huang W, Li FR*. LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells. Stem Cell Res Ther. 2020 ;11(1):163. [IF=8.079]

28.Wang J, Shao L, Wu L, Ma W, Zheng Y, Hu C, Li FR*. Expression levels of a gene signature in hiPSC associated with lung adenocarcinoma stem cells and its capability in eliciting specific antitumor immune-response in a humanized mice model. Thorac Cancer. 2020;11(6):1603-1612. [IF=3.223]

29.Wang J,Wang Y, Han L, Shahen M, Hu C, Li FR*. Multi-Omics Integration Reveals a Competitive Endogenous RNAs Network for the Identification of Progression Biomarkers and the Stratification of Patients Diagnosed With Nephroblastoma. Front Oncol. 2020 ;10:444. [IF=5.738]

30.Zheng YY, Fei Y, Wang Z, Chen Y, Qiu C, Li FR*. Tissue microRNAs in non-small cell lung cancer detected with a new kind of liquid bead array detection system. J Transl Med. 2020;18(1):108. [IF=8.440]

31.Zhang K, Yu L, Li FR*, Li X, Wang Z, Zou X,Zhang C, Lv K, Zhou B, Mitragotri S, Chen M. Topical Application of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells in Combination with Sponge Spicules for Treatment of Photoaging. Int J Nanomedicine. 2020;15:2859-2872. [IF=7.033]

32.Wang C, Huang X, Wu Y, Wang J, Li FR*, Guo G*. Tumor Cell-associated Exosomes Robustly Elicit Anti-tumor Immune Responses through Modulating Dendritic Cell Vaccines in Lung Tumor. Int J Biol Sci. 2020;16(4):633-643. [IF=10.750]

33.Yang XF,Wang HY, Lu WL, Ma W, Zhang H, Li FR*. Direct reprogramming of hepatocytes into insulin-producing cells for anti-diabetic treatment by ultrasound-targeted microbubble destruction enhanced hydrodynamic gene delivery. Am J Transl Res.2020;12(11):7275-7286. [IF=3.940]

发明专利

1.丁琳;李富荣;梁敏莉。一种靶向树突状细胞促进抗原溶酶体逃逸激活免疫系统的抗原递送载体其制备方法与应用。授权号：ZL202210919914.2

2.杨晓菲、李富荣。外泌体冻干粉转运用贮存装置。实用新型，授权号：ZL202322946293X

3.李富荣，李宁，蒋豆蔻，邓春艳。国家发明专利：miRNA-181c促进人源iPS分化为胰岛β细胞的方法。2022-02-11，授权号：ZL201811390681.1

4.王策、李富荣、陈尚。一种抗CD3和EpCAM双特异性抗体及其治疗肺癌中的应用。国家发明专利，2023-5-20，授权号：ZL201810502119.7

5.李富荣，齐晖，李阳,张田田。直接重编程小鼠肝细胞为胰岛β细胞的方法及应用。 授权号：ZL 201510400183.0

6.李富荣，杨璐。基于HCR的液相芯片检测miRNA方法。授权号:ZL201610643310.4

7.李富荣，周淑艳，闫红杰，齐晖，李阳。国家发明专利：一种诱导人诱导多能干细胞定向分化为胰腺细胞的方法。授权号：ZL201510124506.8

8.李富荣,余小舫,王正,费筠.国家发明专利：液相芯片miRNA检测试剂盒. 授权号：ZL2015 1 0256039.4

9.李富荣, 齐晖,孔小丽,任莉莉，孔小丽，周汉新.国家发明专利：一种双标记纳米金探针的制备方法. 授权号：ZL200810215874.3

10.李富荣,周汉新,曹君剑,齐晖,任莉莉.国家发明专利：纳米磁性微球的制备方法.授权号：ZL200510033784.9

11.周汉新,李富荣,韩涛,齐晖,任莉莉.国家发明专利：纳米磁性药物微球及其制备方和应用. 授权号：ZL200510033783.4

专利转化

1. 李富荣，陈辅明，宋丽。基于整合酶活性进行超早期 HIV 感染快速诊断试剂盒及其所含组合物。申请号：2023102279390，转让日期：2023.06.20。

2.李富荣，陈辅明，王婧。一种基于RCA技术的DNA纳米传感器快速检测肺炎克雷伯菌的方法。申请号：2023102279494， 转让日期：2023.06.20。

3.李富荣,余小舫,王正,费筠.国家发明专利：液相芯片miRNA检测试剂盒. 授权号：ZL201510256039.4；转让日期：2019.06.27。

4.李富荣，周淑艳，闫红杰，齐晖，李阳。国家发明专利：一种诱导人诱导多能干细胞定向分化为胰腺细胞的方法。授权号：ZL201510124506.8；转让日期：2019.06.27。