临床双聘教授

近年发表文章

1. Ding C, Shi Z, Ou M, Li Y, Huang L, Wang W, Huang Q, Li M, Chen C, Zeng X, Chen H, Mei L. Dextran-based micelles for combinational chemo-photodynamic therapy of tumors via in vivo chemiluminescence. Carbohydrate Polymers, 2023, 39: 121192.

2. Liu N, Zhou Q, Wang H, Li Q, Chen Z, Lin Y, Yi L, Jiang S, Chen C, Deng Y. MiRNA-338-3p Inhibits Neuroinflammation in the Corpus Callosum of LCV-LPS Rats Via STAT1 Signal Pathway. Cell Mol Neurobiol, 2023. DOI: 10.1007/s10571-023-01378-w.

3. Chen W, Fang M, Chen C. Gas embolism caused by gas-forming pyogenic liver abscess. J Transl Int Med, 2023, 11(2): 189-192.

4. Deng J, He L, Liang Y, Hu L, Xu J, Fang H, Li Y, Chen C. Serum N-terminal pro-B-type natriuretic peptide and cystatin C for acute kidney injury detection in critically ill adults in China: a prospective, observational study. BMJ Open, 2023, 13(1): e063896.

5. Wang Y, Chen J, Du J, Lei L, Zhao B, Bai Y, Chen D, Wang X, Chen C. The Determination of Polymyxin B in Critically Ill Patients by the HPLC-MS/MS Method. Int J Anal Chem, 2023, 2023: 6674009.

6. Li Y, Jiang X, Chen J, Hu Y, Bai Y, Xu W, He L, Wang Y, Chen C, Chen J. Evaluation of the contribution of gut microbiome dysbiosis to cardiac surgery-associated acute kidney injury by comparative metagenome analysis. Front Microbiol, 2023, 14: 1119959.

7. Bai Y, Huang W, Jiang X, Xu W, Li Y, Wang Y, Huang S, Wu K, Hu L, Chen C. Metabolomic interplay between gut microbiome and plasma metabolome in cardiac surgery-associated acute kidney injury. Rapid Commun Mass Spectrom, 2023, 37(11): e9504.

8. Shao X, Li J, Zhang H, Zhang X, Sun C, Ouyang X, Wang Y, Wu X, Chen C. Anti-inflammatory effects and molecular mechanisms of bioactive small molecule garlic polysaccharide. Front Nutr, 2023, 9: 1092873.

9. He L, Liang S, Liang Y, Fang M, Li J, Deng J, Fang H, Li Y, Jiang X, Chen C. Defining a postoperative mean arterial pressure threshold in association with acute kidney injury after cardiac surgery: a prospective observational study. Intern Emerg Med, 2023, 18(2): 439-448.

10. Fang M, Li J, Fang H, Wu J, Wu Z, He L, Deng J, Chen C. Prediction of acute kidney injury after total aortic arch replacement with serum cystatin C and urine N-acetyl-β-d-glucosaminidase: A prospective observational study. Clin Chim Acta, 2023, 539: 105-113.

11. Liang M, Hu L, Luo N, Lv H, Chen Z, Mo J, Yang M, Lin Y, Chen C. Effects of Juhongtanke oral solution on alleviating the symptoms of community-acquired pneumonia: A multicenter, prospective, randomized controlled trial. Front Pharmacol, 2022, 13: 1027901.

12. Wu G, Hui X, Hu L, Bai Y, Rahaman A, Yang XF, Chen C. Recent advancement of bioinspired nanomaterials and their applications: A review. Front Bioeng Biotechnol, 2022, 10: 952523.

13. Hu L, Qiu H, Liu L, Guérin C, Chen C. Editorial: Acute respiratory distress syndrome and mechanical ventilation. Front Med (Lausanne), 2022, 9: 994611.

14. Bai Y, Li Y, Tang Z, Hu L, Jiang X, Chen J, Huang S, Wu K, Xu W, Chen C. Urinary proteome analysis of acute kidney injury in post-cardiac surgery patients using enrichment materials with high-resolution mass spectrometry. Front Bioeng Biotechnol,. 2022, 10: 1002853.

15. Ouyang X, He Z, Fang H, Zhang H, Yin Q, Hu L, Gao F, Yin H, Hao T, Hou Y, Wu Q, Deng J, Xu J, Wang Y, Chen C. A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway. Mol Ther, 2023, 31(6): 1722-1738.

16. Ding C, Chen C, Zeng X, Chen H, Zhao Y. Emerging Strategies in Stimuli-Responsive Prodrug Nanosystems for Cancer Therapy. ACS Nano, 2022, 16(9): 13513-13553.

17. Fang H, Fang M, Wang Y, Zhang H, Li J, Chen J, Wu Q, He L, Xu J, Deng J, Liu M, Deng Y, Chen C. Indole-3-Propionic Acid as a Potential Therapeutic Agent for Sepsis-Induced Gut Microbiota Disturbance. Microbiol Spectr, 2022, 10(3): e0012522.

18. Hu L, Peng K, Huang X, Wang Z, Wu Q, Xiao Y, Hou Y, He Y, Zhou X, Chen C. Ventilator-associated pneumonia prevention in the Intensive care unit using Postpyloric tube feeding in China (VIP study): study protocol for a randomized controlled trial. Trials, 2022,  23(1): 478.

19. Fang H, Wang Y, Deng J, Zhang H, Wu Q, He L, Xu J, Shao X, Ouyang X, He Z, Zhou Q, Wang H, Deng Y, Chen C. Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice. mSystems, 2022, 7(3): e0139921.

20. Hu L, Peng K, Huang X, Wang Z, Wu Y, Zhu H, Ma J, Chen C. A novel strategy sequentially linking mechanical cardiopulmonary resuscitation with extracorporeal cardiopulmonary resuscitation optimizes prognosis of refractory cardiac arrest: an illustrative case series. Eur J Med Res, 2022, 27(1): 77.

21. Xu J, Li S, Chen X, Tan B, Chen S, Hu B, Nie Z, Ye H, Sun C, Chi R, Chen C. A Two-Stage Bedside Intubation Method to Improve Success Rate of Post-pyloric Placement of Spiral Nasoenteric Tubes in Critically Ill Patients: A Multi-Center, Prospective Study. Front Med (Lausanne), 2022, 9: 875298.

22. Li J, Chen J, Zhao M, Li Z, Liu N, Fang H, Fang M, Zhu P, Lei L, Chen C. Downregulated ALKBH5 contributes to myocardial ischemia/reperfusion injury by increasing m6A modification of Trio mRNA. Ann Transl Med, 2022, 10(7): 417.

23. Wu Z, Lan J, Wang X, Wu Y, Yao F, Wang Y, Zhao BX, Wang Y, Chen J, Chen C. Population Pharmacokinetics of Caspofungin and Dose Simulations in Heart Transplant Recipients. Antimicrob Agents Chemother, 2022, 66(5): e0224921.

24. Zhang H, Xu J, Wu Q, Fang H, Shao X, Ouyang X, He Z, Deng Y, Chen C. Gut Microbiota Mediates the Susceptibility of Mice to Sepsis-Associated Encephalopathy by Butyric Acid. J Inflamm Res, 2022, 15: 2103-2119.

25. Bai Y, Wang G, Lan J, Wu P, Liang G, Huang J, Wu Z, Wang Y, Chen C. Mass Spectrometric Behavior and Molecular Mechanisms of Fermented Deoxyanthocyanidins to Alleviate Ulcerative Colitis Based on Network Pharmacology. Int J Anal Chem, 2022, 2022: 9293208.

26. Liang S, Luo D, Hu L, Fang M, Li J, Deng J, Fang H, Zhang H, He L, Xu J, Liang Y, Chen C. Variations of urinary N-acetyl-β-D-glucosaminidase levels and its performance in detecting acute kidney injury under different thyroid hormones levels: a prospectively recruited, observational study. BMJ Open, 2022, 12(3): e055787.

27. Bai Y, Zhang H, Wu Z, Huang S, Luo Z, Wu K, Hu L, Chen C. Use of ultra high performance liquid chromatography with high resolution mass spectrometry to analyze urinary metabolome alterations following acute kidney injury in post-cardiac surgery patients. J Mass Spectrom Adv Clin Lab, 2022, 24:31-40.

28. Hu L, Gao L, Zhang D, Hou Y, He LL, Zhang H, Liang Y, Xu J, Chen C. The incidence, risk factors and outcomes of acute kidney injury in critically ill patients undergoing emergency surgery: a prospective observational study. BMC Nephrol, 2022, 23(1): 42.

29. Lan J, Wu Z, Wang X, Wang Y, Yao F, Zhao BX, Wang Y, Chen J, Chen C. Population Pharmacokinetics Analysis and Dosing Simulations Of Meropenem in Critically Ill Patients with Pulmonary Infection. J Pharm Sci, 2022, 111(6): 1833-1842.

30. Hou Y, Deng Y, Hu L, He L, Yao F, Wang Y, Deng J, Xu J, Wang Y, Xu F, Chen C. Assessment of 17 clinically available renal biomarkers to predict acute kidney injury in critically ill patients, J Transl Int Med. 2021, 9(4): 273-284.

31. Lv B, Hu L, Fang H, Sun D, Hou Y, Deng J, Zhang H, Xu J, He L, Liang Y, Chen C. Development and Validation of a Nomogram Incorporating Colloid Osmotic Pressure for Predicting Mortality in Critically Ill Neurological Patients. Front Med (Lausanne), 2021, 8: 765818.

32. Tao X, Chen C, Luo W, Zhou J, Tian J, Yang X, Hou FF. Combining renal cell arrest and damage biomarkers to predict progressive AKI in patient with sepsis. BMC Nephrol, 2021, 22(1): 415.

33. Bai Y, Li J, Wang G, Liang G, He Y, Hu L, Chen C. Mass spectrometric behaviors and molecular mechanisms of Amadori compounds between acute lung injury and diabetes based on network pharmacology. Ann Palliat Med, 2021,10(12): 12441-12455.

34. Jiang S, Wang H, Zhou Q, Li Q, Liu N, Li Z, Chen C, Deng Y. Melatonin Ameliorates Axonal Hypomyelination of Periventricular White Matter by Transforming A1 to A2 Astrocyte via JAK2/STAT3 Pathway in Septic Neonatal Rats. J Inflamm Res, 2021, 14: 5919-5937.

35. Lai C, Liu X, Yan Q, Lv H, Zhou L, Hu L, Cai Y, Wang G, Chen Y, Chai R, Liu Z, Xu Y, Huang W, Xiao F, Hu L, Li Y, Huang J, Zhou Q, Li L, Peng T, Zhang H, Zhang Z, Chen L, Chen C, Ji T. Low Innate Immunity and Lagged Adaptive Immune Response in the Re-Tested Viral RNA Positivity of a COVID-19 Patient. Front Immunol, 2021, 12: 664619

36. Ouyang X, Qu R, Hu B, Wang Y, Yao F, Lv B, Sun C, Deng Y, Chen C. Is metoclopramide beneficial for the postpyloric placement of nasoenteric tubes? A systematic review and meta-analysis of randomized controlled trials. Nutr Clin Pract, 2022, 37(2): 316-327.

37. Wang X, Wang Y, Yao F, Chen S, Hou Y, Zheng Z, Luo J, Qiu B, Li Z, Wang Y, Wu Z, Lan J, Chen C. Pharmacokinetics of Linezolid Dose Adjustment for Creatinine Clearance in Critically Ill Patients: A Multicenter, Prospective, Open-Label, Observational Study. Drug Des Devel Ther, 2021, 15: 2129-2141.

38. Ma J, Deng Y, Lao H, Ouyang X, Liang S, Wang Y, Yao F, Deng Y, Chen C. A nomogram incorporating functional and tubular damage biomarkers to predict the risk of acute kidney injury for septic patients. BMC Nephrol, 2021, 22(1): 176.

39. Wei R, Chen X, Hu L, He Z, Ouyang X, Liang S, Dai S, Sha W, Chen C. Dysbiosis of intestinal microbiota in critically ill patients and risk of in-hospital mortality. Am J Transl Res, 2021, 13(3): 1548-1557.

40. Bai Y, Huang W, Li Y, Lai C, Huang S, Wang G, He Y, Hu L, Chen C. Lipidomic alteration of plasma in cured COVID-19 patients using ultra high-performance liquid chromatography with high-resolution mass spectrometry. Biosci Rep, 2021, 41(3): BSR20204305.

41. Bai Y, Liang Y, Li G, Wu S, Wang G, Li Y, Liu Y, Chen C. Metal-ion-assisted structural and anomeric analysis of Amadori compounds by electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom, 2021, 35(1): e8960.

42. Wu QR, Zheng DL, Liu PM, Yang H, Li LA, Kuang SJ, Lai YY, Rao F, Xue YM, Lin JJ, Liu SX, Chen CB, Deng CY. High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy. Cell Death Dis, 2021, 12(2): 216.

43. Chen W, Li J, Deng R, Chen C. Case report: tracheoesophageal fistula secondary to post-intubation tracheomegaly in a tetanus patient. Ann Palliat Med, 2021, 10(4): 4922-4925.

44. Qu R, Hu L, Ling Y, Hou Y, Fang H, Zhang H, Liang S, He Z, Fang M, Li J, Li X, Chen C. C-reactive protein concentration as a risk predictor of mortality in intensive care unit: a multicenter, prospective, observational study. BMC Anesthesiol, 2020, 20(1): 292.

45. Deng Y, Ma J, Hou Y, Zhou D, Hou T, Li J, Liang S, Tan N, Chen C. Combining Serum Cystatin C and Urinary N-Acetyl-Beta-D-Glucosaminidase Improves the Precision for Acute Kidney Injury Diagnosis after Resection of Intracranial Space-Occupying Lesions. Kidney Blood Press Res, 2020, 45(1): 142-156.

46. Shao X, Sun C, Tang X, Zhang X, Han D, Liang S, Qu R, Hui X, Shan Y, Hu L, Fang H, Zhang H, Wu X, Chen C. Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic (Allium sativum L.) Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis. J Agric Food Chem, 2020, 68(44): 12295-12309.

47. Yao F, Wang Y, Hou Y, Wang X, Lan J, Wu Z, Wang Y, Chen C. Establishment and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Tigecycline in Critically Ill Patients. Int J Anal Chem, 2020, 2020: 6671392.

48. Huang P, Chen X, Hu X, Zhou Q, Lin L, Jiang S, Fu H, Xiong Y, Zeng H, Fang M, Chen C, Deng Y. Experimentally Induced Sepsis Causes Extensive Hypomyelination in the Prefrontal Cortex and Hippocampus in Neonatal Rats. Neuromolecular Med, 2020, 22(3): 420-436.

49. He Z, Hu L, Chen C. Response to the letter: Comment on "simo decoction versus domperidone suspension for post-pyloric spiral nasoenteric tube placement: A multicenter, randomized, non-inferiority trial". Clin Nutr, 2020, 39(12): 3847-3848.

50. Liang S, Shi M, Bai Y, Deng Y, Fang M, Li J, Wu Y, Peng W, Hou Y, Fang H, Zhang H, Chen C. The effect of glucocorticoids on serum cystatin C in identifying acute kidney injury: a propensity-matched cohort study. BMC Nephrol, 2020, 21(1): 519.

51. Xiao Y, He Z, Long Y, Chen W, Chen D, Chi R, Ye H, Deng X, Lv B, Sun C, Hu B, Nie Z, Gu S, Chen C. Simo decoction versus domperidone suspension for post-pyloric spiral nasoenteric tube placement: A multicenter, randomized, non-inferiority trial. Clin Nutr, 2020, 39(8): 2406-2412.

发明专利

1. 陈纯波，黄金波，胡林辉，吴宪君，一种抗蛋白吸附鼻肠管及制备方法，澳大利亚革新专利，AU2021106511A，2021/10/20

2. 陈纯波，黄金波，一种鼻饲管自动收纳装置，实用新型专利，ZL202020612890.2，2021/7/27

3. 陈纯波，黄金波，一种鼻饲管手动收纳装置，实用新型专利，ZL202020612892.1，2021/3/9

4. 陈纯波，黄金波，一种仿生结构的鼻肠管，实用新型专利，ZL202021227648.X，2021/7/27

5. 陈纯波，黄金波，一种仿生结构的鼻肠管，发明专利，ZL202010605810.5，2020/10/27

6. 陈纯波，胡林辉，黄金波，一种鼻饲管，实用新型专利，ZL202121606946.4，2022/7/1

7. 计算机软件著作权，重症患者急性肾损伤的风险预测软件，著作权人：陈纯波，登记号2019SR0947923，2019/9/11

8. 计算机软件著作权，肠道组学预测ICU患者死亡率系统1.0，著作权人：陈纯波。登记号2021SR1951247,2021/11/30

专利转化

广东先来医疗器械有限公司以18.06万元实现对ZL202020612890.2、ZL202020612892.1、ZL202021227648.X、ZL202010605810.5成果转化