临床双聘教授
近年发表文章（#并列第一作者；*通讯作者）
1. Qiongzhen Zeng#, Menghe Li#, Hengyuan Gao#, Kai Zheng, Weixiangmin Zou, Caiwenjie La, Leyi Fu, Xiaodi Liu*, Yifei Wang*, Kaisheng Liu*. HDAC6 regulates α-tubulin to inhibit STING/NLRP3-mediated microglial pyroptosis induced by HSV-1 infection. Journal of infectious diseases. 2025 Aug 8:jiaf404. doi: 10.1093/infdis/jiaf404.(Co-corresponding author) 2区，Q1，IF=4.5
2. Qingyue Ye, Haopeng Wang, Qiu Yang, Qiaochu Yang, Zesen Li, Zhuo Zhang, Yifei Wang, Kaisheng Liu*, Yang Ran*. Triple-optimization fiber-optic endotoxin-sensing strategy utilizing Limulus Amebocyte Lysate (LAL). Talanta. 2025 JUL 297:128520. doi:10.1016/j.talanta.(Co-corresponding author)2区，Q1，IF=6.1
3. Qiongzhen Zeng#, Zixin Chen#, Shan Li, Ziwei Huang, Zhe Ren, Cuifang Ye, Xiao Wang, Jun Zhou, Kaisheng Liu*, Kai Zheng*, Yifei Wang*. HDAC6 deacetylates TRIM56 to negatively regulate cGAS-mediated type I interferon response. EMBO reports. 2025 Feb;26(3):720-747. doi: 10.1038/s44319-024-00358-5. (Co-corresponding author) 1区，Q1，IF=6.5
4. Zhuo Zhang#, Xu Yue#, Ni Lan, Yongkang Zhang, Zesen Li, Fangzhou Jin, Yifei Wang, Bai-Ou Guan, Yang Ran*, Kaisheng Liu*. Effective antitumor synergistic treatment with fiber- photothermal therapy and heat shock protein inhibitors. ACS Applied Materials & Interfaces. 2025 Jan 22;17(3):4368-4379. (Co-corresponding author) 2区，Q1，IF=8.3
5. Ni Lan#, Yuan Su#, Qiongzhen Zeng#, Pengjun Zhou, Yuze Hu, Zhuo Zhang, Yifei Wang*, Kaisheng Liu*. JD-02, a novel Hsp90 inhibitor, induces ROS/SRC axis-dependent cytoprotective autophagy in colorectal cancer cells. Molecular Carcinogenesis. 2024 Jun;63(6):1038-1050. doi: 10.1002/mc.23706. (Co-corresponding author) 4区，Q2，IF=3.2
6. Hongxiang Jiang#, Ni Lan#, Wenhui Ma, Zhuo Zhang, Zibo Zhao, Yuze Hu, Yuan Su, Yunsheng Huang, Yifei Wang, Daohua Xu*, Kaisheng Liu*. Synthesis and evaluation of the antitumor activity of 2-amino-4-tetrahydroindazole-substituted benzamide derivatives as HSP90 inhibitors. Journal of Molecular Structure. 2024;1300:137266. (Co-corresponding author) 2区，Q2,IF=4.7
7. Zeyu Li#, Liecong Xue#, Junxian Yang, Stefan Wuttke*, Peiying He, Chuanyi Lei, Haowei Yang, Liang Zhou, Jiangfan Cao, Anna Sinelshchikova, Guansheng Zheng, Jimin Guo, Jiangguo Lin, Qi Lei, C. Jeffrey Brinker, Kaisheng Liu*, Wei Zhu*. Synthetic Biohybrids of Red Blood Cells and Cascaded-Enzymes@ Metal-Organic Frameworks for Hyperuricemia Treatment. Advanced Science. 2024 Feb;11(5):e2305126. doi: 10.1002/advs.202305126. (Co-corresponding author) 1区，Q1，IF=14.1
8. Lishan Zhong#, Yanting Wu#, Chen Huang, Kaisheng Liu*, Cui-fang Ye, Zhe Ren, Yifei Wang*. Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats. BMC Pharmacology & Toxicology. 2023 Oct 13;24(1):54. doi: 10.1186/s40360-023-00696-5. (Co-corresponding author) 3区，Q2，IF=2.7
9. Fanhui Kong#, Qi Lei#,*, Yi Ma#,*, Peiying He, Guansheng Zheng, Yue Xu, Junda Huang, C. Jeffrey Brinker, Kaisheng Liu*, Wei Zhu*. Membrane Fusion Liposome-Mediated Ferroptosis Explosion for Enhanced Cancer Therapy. Chemistry of Materials. 2023;35(12):4731–4742. DOI: 10.1021/acs.chemmater.3c00444. (Co-corresponding author)2区，Q1，IF=7
10. Qiang Fu#, Hengyuan Gao#, Kaisheng Liu#, Juan Su, Jianglin Zhang, Xiaojing Guo*, Fang Yang*. Identification of circRNA-miRNA-mRNA network regulated by Hsp90 in human melanoma A375 cells. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING. 2024;27(2):307-316. doi: 10.2174/1386207326666230609145247. (Co-first author) 4区，Q3，IF=1.7
11. Min Chen#, Yanke Lin#, Yongkang Dang, Yifei Xiao, Fugui Zhang, Guanghui Sun, Xuejun Jiang, Li Zhang, Jianhao Du, Shuyi Duan, Xiaojian Zhang, Zifei Qin*, Jing Yang*, Kaisheng Liu*, Baojian Wu*. Reprogramming of rhythmic liver metabolism by intestinal clock. Journal of Hepatology. 2023 Sep;79(3):741-757. doi: 10.1016/j.jhep.2023.04.040. (Co-corresponding author) 1区，Q1，IF=33
12. Houxiang Jiang#, Shaoxiang Wang#, Ying Liu#, Chaopan Zheng#, Lipeng Chen, Kai Zheng, Zhenyu Xu, Yong Dai, Hongtao Jin, Zhiqiang Cheng, Chang Zou, Li Fu*, Kaisheng Liu*, Xiaoshi Ma*. Targeting EFNA1 suppresses tumor progression via the cMYC-modulated cell cycle and autophagy in esophageal squamous cell carcinoma. Discover Oncology. 2023 May 9;14(1):64. doi: 10.1007/s12672-023-00664-9. (Co-corresponding author) 4区，Q2，IF=2.9
13. Peiying He#, Qi Lei#, Bin Yang*, Tongyi Shang, Jianjun Shi, Qing Ouyang, Wei Wang, Liecong Xue, Fanhui Kong, Zeyu Li, Junda Huang, Lihan Liu, Jimin Guo, C Jeffrey Brinker, Kaisheng Liu*, Wei Zhu*. Dual-Stage Irradiation of Size-Switchable Albumin Nanocluster for Cascaded Tumor Enhanced Penetration and Photothermal Therapy. ACS Nano. 2022 Sep 27;16(9):13919-13932. doi: 10.1021/acsnano.2c02965. (Co-corresponding author)1区，Q1，IF=16.1
14. Min Chen, Li Zhang, Mingting Shao, Jianhao Du, Yifei Xiao, Fugui Zhang, Tianpeng Zhang, Yifang Li, Qianqian Zhou, Kaisheng Liu*, Zhigang Wang*, Baojian Wu*. E4BP4 Coordinates Circadian Control of Cognition in Delirium. Advanced Science. 2022 Aug;9(23):e2200559. doi: 10.1002/advs.202200559. (Co-corresponding author) 1区，Q1，IF=15.1
15. Huibin Song#, Dongcheng Liu#, Lingwei Wang#, Kaisheng Liu#, Chen Chen#, Le Wang, Yi Ren, Bing Ju, Fuhua Zhong, Xingyu Jiang, Guangsuo Wang*, Zhe-Sheng Chen*, Chang Zou*. Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma. Molecular Cancer. 2022 Feb 10;21(1):43. doi: 10.1186/s12943-022-01519-7. (Co-first author) 1区，Q1，IF=33.9
16. Fangjun Yu#, Zhigang Wang#, Tianpeng Zhang, Xun Chen, Haiman Xu, Fei Wang, Lianxia Guo, Min Chen, Kaisheng Liu*, Baojian Wu*. Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding. Nature Communications. 2021 Sep 7;12(1):5323. doi: 10.1038/s41467-021-25674-5. (Co-corresponding author) 1区，Q1， IF=15.7
17. Xiaoshi Ma#, Jinan Guo#, Kaisheng Liu#, Lipeng Chen, Dale Liu, Shaowei Dong, Jinquan Xia, Qiaoyun Long, Yongjian Yue, Pan Zhao, Fengyan Hu, Zhangang Xiao, Xinghua Pan, Kefeng Xiao, Zhiqiang Cheng, Zunfu Ke, Zhe-Sheng Chen, Chang Zou. Identification of a distinct luminal subgroup diagnosing and stratifying early stage prostate cancer by tissue-based single-cell RNA sequencing. Molecular Cancer. 2020 Oct 8;19(1):147. doi: 10.1186/s12943-020-01264-9. (Co-first author) 1区，Q1，IF=33.9
18. Kaisheng Liu#, Lin Gao#, Xiaoshi Ma#, Juan-Juan Huang, Juan Chen, Leli Zeng, Charles R Ashby Jr, Chang Zou*, Zhesheng Chen*. Long non-coding RNAs regulate drug resistance in cancer. Molecular Cancer. 2020 Mar 12;19(1):54. doi: 10.1186/s12943-020-01162-0. (Co-first author) 1区，Q1，IF=33.9
19. Kaisheng Liu, Xiao Wang, Chang Zou*, Jieting Zhang, Hao Chen, Lailing Tsang, Mei Kuen Yu, Yiu Wa Chung, Jianhong Wang, Yong Dai*, Yang Liu*, Xiaohu Zhang*. Defective CFTR promotes intestinal proliferation via inhibition of the hedgehog pathway during cystic fibrosis. Cancer Letters. 2019 Apr 1;446:15-24. doi: 10.1016/j.canlet.2018.12.018. (Co-first author)1区，Q1,IF=10.1
20. Kaisheng Liu#, Hui Liu#, Jinhuan Qi, Qiuyun Liu, Zhong Liu, Min Xia, Guowen Xing, Shaoxiang Wang*, Yifei Wang*. SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells. Cancer Letters. 2012 May 28;318(2):180-8. doi: 10.1016/j.canlet.2011.12.015. (Co-first author) 1区，Q1, IF=10.1
21. Jiahui Zhou#, Wene Wei#, Hu Hou#, Shufang Ning, Jilin Li, Baoyue Huang, Kaisheng Liu*, Litu Zhang*. Prognostic Value of C-Reactive Protein, Glasgow Prognostic Score, and C-Reactive Protein-to-Albumin Ratio in Colorectal Cancer. Frontiers in Cell and Developmental Biology. 2021 Oct 26;9:637650. doi: 10.3389/fcell.2021.637650. (Co-corresponding author) 2区，Q2,IF=4.3
22. Haizhou Liu#, Zihan Zhang#, Yi Huang#, Wene Wei, Shufang Ning, Jilin Li, Xinqiang Liang, Kaisheng Liu*, Litu Zhang*. Plasma HSP90AA1 Predicts the Risk of Breast Cancer Onset and Distant Metastasis. Frontiers in Cell and Developmental Biology. 2021 May 24;9:639596. doi: 10.3389/fcell.2021.639596. (Co-corresponding author) 2区，Q2，IF=4.3
23. Yi Ma, Liu Cui, Meng Wang, Qiuli Sun, Kaisheng Liu*, Jufang Wang*. A Novel and Efficient High-Yield Method for Preparing Bacterial Ghosts. Toxins. 2021 Jun 13;13(6):420. doi: 10.3390/toxins13060420. (Co-corresponding author) 3区，Q2，IF=4
24. Nan Li#, Kaisheng Liu#, Shaowei Dong, Ling Ou, Jieling Li, Minshan Lai, Yue Wang, Yucheng Bao, Huijie Shi, Xiao Wang*, Shaoxiang Wang*. Identification of CHRNB4 as a Diagnostic/Prognostic Indicator and Therapeutic Target in Human Esophageal Squamous Cell Carcinoma. Frontiers in Oncology. 2020 Nov 16;10:571167. doi: 10.3389/fonc.2020.571167. (Co-first author)3区，Q2，IF=3.3
25. Kaisheng Liu, Juan Chen, Fang Yang, Zhifan Zhou, Ying Liu, Yaomin Guo, Hong Hu, Hengyuan Gao, Haili Li, Wenbin Zhou*, Bo Qin*, Yifei Wang*. BJ-B11, an Hsp90 Inhibitor, Constrains the Proliferation and Invasion of Breast Cancer Cells. Frontiers in Oncology. 2019 Dec 18;9:1447. doi: 10.3389/fonc.2019.01447.(Co-first author)3区，Q2，IF=3.3
26. Kaisheng Liu#, Minshan Lai#, Shaoxiang Wang, Kai Zheng, Shouxia Xie*, Xiao Wang*. Construction of a CXC Chemokine-Based Prediction Model for the Prognosis of Colon Cancer. Biomed Research International. 2020 Mar 30;2020:6107865. doi: 10.1155/2020/6107865. (Co-first author)4区，Q3，IF=2.3
27. Kaisheng Liu, Fajin Dong, Hengyuan Gao, Yaomin Guo, Haili Li, Fang Yang, Pan Zhao, Yong Dai, Jianhong Wang*, Wenbin Zhou*, Chang Zou*. Promoter hypermethylation of the CFTR gene as a novel diagnostic and prognostic marker of breast cancer. Cell Biology International. 2020 Feb;44(2):603-609. doi: 10.1002/cbin.11260. (Co-first author)3区，Q3，IF=3.1
28. Kaisheng Liu, Yaomin Guo, Kai Zheng, Chang Zou, Haixiong Wu, Shaoxiang Wang, Ling Ou, Yifei Wang, Bowan Huang*, Xiao Wang*. Identification of the circRNA-miRNA-mRNA regulatory network of Hsp90 inhibitor-induced cell death in colorectal cancer by integrated analysis. Gene. 2020 Feb 15;727:144232. doi: 10.1016/j.gene.2019.144232. (Co-first author)3区，Q2，IF=2.4
29. Kai-Sheng Liu, Cheng Zhang, Hong-Liang Dong, Kai-Kai Li, Quan-Bin Han, Yong Wan, Rui Chen, Fang Yang, Hai-Li Li, Chun-Hay Ko*, Xiao-Qiang Han*. GSP-2, a polysaccharide extracted from Ganoderma sinense, is a novel toll-like receptor 4 agonist. PLoS One. 2019 Aug 23;14(8):e0221636. doi: 10.1371/journal.pone.0221636. (Co-first author)3区，Q2，IF=2.6
30. Kaisheng Liu, Zhifan Zhou, Hengyuan Gao, Fang Yang, Yajun Qian, Hongtao Jin, Yaomin Guo, Ying Liu, Haili Li, Cheng Zhang, Jinan Guo*, Yong Wan*, Rui Chen*. JQ1, a BET-bromodomain inhibitor, inhibits human cancer growth and suppresses PD-L1 expression. Cell Biology International. 2019 Jun;43(6):642-650. doi: 10.1002/cbin.11139. (Co-first author)3区，Q3，IF=3.1
31. Kaisheng Liu, Hongtao Jin, Yaomin Guo, Ying Liu, Yong Wan, Pan Zhao, Zhifan Zhou, Jianhong Wang, Maolin Wang, Chang Zou, Weiqing Wu*, Zhiqiang Cheng*, Yong Dai*. CFTR interacts with Hsp90 and regulates the phosphorylation of AKT and ERK1/2 in colorectal cancer cells. FEBS Open Bio. 2019 Jun;9(6):1119-1127. doi: 10.1002/2211-5463.12641. (Co-first author)4区，Q3，IF=2.3
32. Kaisheng Liu#, Xiaohu Zhang#, Jie Ting Zhang, Lai Ling Tsang, Xiaohua Jiang*, Hsiao Chang Chan*. Defective CFTR- β-catenin interaction promotes NF-κB nuclear translocation and intestinal inflammation in cystic fibrosis. Oncotarget. 2016 Sep 27;7(39):64030-64042. doi: 10.18632/oncotarget.11747. (Co-first author) IF=5.168
33. Kaisheng Liu#, Yi Zhang#, Weichao Ding, Shaoxiang Wang, Yangfei Xiang, Pan Yang, Zhenping Chen, Kai Zheng, Zhong Liu, Min Xia, Yifei Wang. The selective Hsp90 inhibitor BJ-B11 exhibits potent antitumor activity via induction of cell cycle arrest, apoptosis and autophagy in Eca-109 human esophageal squamous carcinoma cells. International Journal of Oncology. 2012 Dec;41(6):2276-84. doi: 10.3892/ijo.2012.1670. (Co-first author) 3区，Q1，IF=43.9
34. Kaisheng Liu#, Weichao Ding#, Shaoxiang Wang, Zhong Liu, Guowen Xing, Ying Wang*, Yifei Wang*. The heat shock protein 90 inhibitor SNX-2112 inhibits B16 melanoma cell growth in vitro and in vivo. Oncology Reports. 2012 Jun;27(6):1904-10. doi: 10.3892/or.2012.1738. (Co-first author)3区，Q2，IF=3.9
发明专利
(1) 发明人：刘凯胜，蓝妮，苏苑，任哲，王一飞，名称：四氢吲唑类抗肿瘤化合物的制备方法及其应用，发明专利，专利号：202310434237.X
(2) 发明人：刘凯胜，王泽旭，蓝妮，任哲，王一飞，名称：一种苯甲酰胺类化合物及其制备方法、使用方法和应用，发明专利，专利号：ZL202310453768.3
(3) 发明人：刘凯胜，王泽旭，苏苑，蓝妮，王一飞，名称：苯甲酰胺类化合物及制备方法、使用方法和应用，发明专利，专利号：ZL202310475230.2
(4) 发明人：刘凯胜，苏苑，张卓，蓝妮，任哲，王一飞，名称：四氢吲唑化合物、制备方法及其在治疗食管鳞癌中的应用，发明专利，专利号：ZL202310529793.5
(5) 发明人：刘凯胜，蒋宏香，蓝妮，周朋君，马文辉，名称：一种四氢吲唑类化合物及其制备方法和应用，发明专利，专利号：ZL202210158435.3
(6) 发明人：刘凯胜，戴勇，王建红，成志强，周文斌，名称：一种用于乳腺癌早期筛查的检测试剂、试剂盒及检测试剂的应用，发明专利，专利号：ZL201910451150.7
(7) 发明人：刘凯胜，王建红，王一飞，邹畅，戴勇，名称：CFTR抑制剂在制备调节Hedgehog信号通路的试剂中的应用，发明专利，专利号：ZL201811337213.8