校内双聘教授

1. Shi, Y., Xu, M., Huang, Y., Qu, J., Liao, S., Liu, Y., Li, L. (李亮，通讯作者). (2025).  Exploring Microorganism-Host Interactions: Emerging Organoid Models and Analytical Approaches. mLife. (Accepted). (IF: 4.6)

2. Fan, H., Tan, Y., Zhang, J., Liu, X., Qu, J., Chua, D., Cheng, H.S., Kim, J.H.S., Qin, C., Liu, Y., Chi, M., Zhang, Q., Li, Y., Joibari, M.M., Pierrou, S., Nilsson, S.K., Tan, N.S., Fan, Y., Li, L. (李亮，通讯作者). (2025). Inhaled Angiopoietin-like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis. Advanced Science. (Accepted). (IF: 14.3)

3. Zhang, R., Yao, F., Huang Y., Liu, W., Liao, S., He, J., Li, S., Wang, Z., Li, L. (李亮，通讯作者), Zhang, G. (2025). Modeling Mycobacterium tuberculosis Pathogenesis in Lung Epithelial Organoids Reveals Strain-Specific Host Responses and Intercellular Crosstalk. Journal of Biological Chemistry.110534. (IF: 3.9)

4. Chen, Y., Qu, J., Wang, S., Tang, M., Liao, S., Liu, Y., Li, L. (李亮，通讯作者), & Wu, B. (2025). Streptococcus agalactiae infection of a reconstructed human respiratory epithelium revealed infection and host response characteristics by different serotypes. Microbial Pathogenesis, 199, 107243. (IF: 3.8)

5. Ke, L., He, Q., Qu, J., Wang, X., Li, K., Gong, X., Li, L., Xu, J., Yu, Q., Yu, H., Lin, X., Li, J., Tan, N. S., Sun, W., Li, L. (李亮，通讯作者), Zhang, P., & Cheng, W. (2024). Bone-protective effects of neutralizing angiopoietin-like protein 4 monoclonal antibody in rheumatoid arthritis. Molecular Therapy. 4:S1525-0016(24)00655-5. (IF: 12.1)

6. Low, Z. S., Chua, D., Cheng, H. S., Tee, R., Tan, W. R., Ball, C., Sahib, N. B. E., Ng, S. S., Qu, J., Liu, Y., Hong, H., Cai, C., Rao, N. C. L., Wee, A., Muthiah, M. D., Bichler, Z., Mickelson, B., Kong, M. S., Tay, V. S., Yan, Z., Chen, J., Ng, A. S., Yip, Y. S., Vos, M. L. G., Tan, N. A., Lim, D. L., Lim, D. X. E., Chittezhath, M., Yaligar, J., Verma, S. K., Poptani, H., Guan, X. L., Velan, S. S., Ali, Y., Li, L.（李亮）, Tan, N. S., Wahli, W. (2024). The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD. Advanced Science. 11(35):e2404326. (IF: 14.3)

7. Li, Y., Zhang, X., Tai, W., Zhuang, X., Shi, H., Liao, S., Yu, X., Mei, R., Chen, X., Huang, Y., Liu, Y., Liu, J., Liu, Y., Zhu, Y., Wang, P., Tian, M., Yu, G., Li, L. (李亮，通讯作者), & Cheng, G. (2024). A substitution at the cytoplasmic tail of the spike protein enhances SARS-CoV-2 infectivity and immunogenicity. EBioMedicine, 110, 105437. 10.1016/j.ebiom.2024.105437. (IF: 9.7)

8. Wang, M., Qu, J., Yang, J., Zhang, T., Tan, W., Liao, S., Chen, X., Liu, Y., Long, X., Li, X., Xia, Y., Tan, N.S., Li, L.(李亮，通讯作者), Fang, M.. (2023) A Missing Jigsaw within the Hygiene Hypothesis: Low-Dose Bisphenol A Exposure Attenuates LPS-Induced Asthma Protection. PNAS Nexus.2(11):pgad312. (IF: 2.2)

9. Zhou, J., Guan, M., Li, R., Qi, Y., Yang, G., Deng, Y., Li, X.-F., Li, L.（李亮）, Yang, X., Liu, J., Qin, C.. (2023). Zika virus leads to olfactory disorders in mice by targeting olfactory ensheathing cells. EBioMedicine. 89:104457. (IF: 11.205)

10. Liao, S., Huang, Y., Zhang, J., Xiong, Q., Chi, M., Yang, L., Zhang, J., Li, L. (李亮，通讯作者), & Fan, Y. (2023). Vitamin D promotes epithelial tissue repair and host defense responses against influenza H1N1 virus and Staphylococcus aureus infections. Respiratory Research. 24(1), 175. 10.1186/s12931-023-02477-4.(IF: 5.8)

11. Liu, L., Fan, H., Li, L. (李亮，通讯作者), & Fan, Y. (2023). Acarbose reduces Pseudomonas aeruginosa respiratory tract infection in type 2 diabetic mice. Respiratory Research. 24(1), 1–19. 10.1186/s12931-023-02619-8. (IF: 5.8)

12. Li, L. （李亮，第一作者）, Aogáin, M.M., Xu, T., Jaggi, T.K., Chan, L.L.Y., Qu, J., Wei, L., Liao, S., Cheng, H.S., Keir, H.R., Dicker, A.J., Tan, K.S., Wang, D.Y., Koh, M.S.,  Ong, T.H., Lim, A.Y.H., Abisheganaden, J.A., Low, T.B., Hassan, T.M., Long, X., Wark, P.A.B., Oliver, B., Drautz-Moses, D.I., Schuster, S.C., Tan, N.S., Fang, M., Chalmers, J.D., and Chotirmall, S.H.. (2022) Neisseria Species as Pathobionts in Bronchiectasis. Cell Host & Microbe. 30(9):1311-1327.e8. (IF: 31.3，封面文章)

13. Tang, M., Liao, S., Qu, J., Liu, Y., Han, S., Cai, Z., Fan, Y., Yang, L., Li, S., and Li, L. （李亮，通讯作者）. (2022) Evaluating Bacterial Pathogenesis Using a Model of Human Airway Organoids Infected with Pseudomonas Aeruginosa Biofilms. Microbiology Spectrum. 02408-22. (IF: 9.0)

14. Tong, L., Xiao, X., Li, M., Fang, S., Ma, E., Yu, X., Zhu, Y., Wu, C., Tian, D., Yang, F., Sun, J., Qu, J., Zheng, N., Liao, S., Tai, W., Feng, S., Zhang, L., Li, Y., Wang, L., Han, X., Sun, S., Yang, L., Zhong, H., Zhao, J., Liu, W., Liu, X., Wang, P., Li, L. (李亮，通讯作者), Zhao, G., Zhang, R., and Cheng, G.. (2022) A Glucose-like Metabolite Deficient in Diabetes Inhibits Cellular Entry of SARS-CoV-2. Nature Metabolism. 4(5):547–58. (IF: 19.9)

15. Tong, L., Wang, L., Liao, S., Xiao, X., Qu, J., Wu, C., Zhu, Y., Tai, W., Huang, Y., Wang, P., Li, L. (李亮，通讯作者), Zhang, R., Xiang, Y., and Cheng, G.. (2022) A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry. mBio. 01485-22. (IF: 7.8)

16. Xu, G., Li, Y., Zhang, S., Peng, H., Wang, Y., Li, D., Jin, T., He, Z., Tong, Y., Qi, C., Wu, G., Dong, K., Gou, J., Liu, Y., Xiao, T., Qu, J., Li,L. （李亮，通讯作者）, Liu, L., Zhao, P., Zhang, Z., Yuan, J.. (2021) SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation. Cell Research. 0:1 – 14. (IF: 46.3)

17. Yang, M., Li, L.（李亮，共一作者）, Huang, T., Li, S., Zhang, M., Yang, Y., Jiang, Y., Li, X., Yuan, J., Liu, Y.. (2021) SARS-CoV-2 Detected on Environmental Fomites for both Asymptomatic and Symptomatic COVID-19 Patients. American Journal of Respiratory and Critical Care Medicine. rccm.202006-2136LE (IF: 30.5)

18. Zhao, F., Yang, Y., Wang, Z., Li, L.（李亮，通讯作者）, Liu, L., Liu, Y.. (2020) The Time Sequences of Oral and Fecal Viral Shedding of Coronavirus Disease 2019 (COVID-19) Patients. Gastroenterology. S0016-5085(20)30663-6 (IF: 33.9)

19. He,Y., Qu, J., Wei, L., Liao, S., Zheng, N., Liu, Y., Wang, X., Jing, Y., Shen, C.K., Ji, C., Luo, G., Zhang, Y., Li, S., Fan, Y., Fang, S., Wang, P., Li,L. （李亮，通讯作者）. (2021) Generation and Effect Testing of a SARS-CoV-2 RBD-Targeted Polyclonal Therapeutic Antibody Based on Airway Organoid Screening System. Frontiers in Immunology. 12:689065 (IF: 8.8)

20. Tang, M., Li, S., Wei, L., Qu, J., Li, L. （李亮，通讯作者）. (2021) Do engineered nanomaterials affect immune responses by interacting with gut microbiota? Frontiers in Immunology. 12:684605 (IF: 8.8)

21. Shi, Y., Lin, J., Tao, X., Qu, J., Liao, S., Li, M., Deng, K., Du, P., Liu, K., Thissen, H., Li, L. (李亮，通讯作者), Kingshott, P., and Wang, P-Y. (2021) Harnessing Colloidal Self-Assembled Patterns (cSAPs) to Regulate Bacterial and Human Stem Cell Response at Biointerfaces In Vitro and In Vivo. ACS Applied Materials & Interfaces. 2021, 13, 18, 20982–20994 (IF: 10.4)

22. Li, L.（李亮，第一作者）, Chong, H.C., Ng, S.Y., Kwok, K.W., Teo, Z., Tan, E.H.P., Choo, C.C., Seet, J.E., Choi. H.W., Buist, M.L., Chow, V.T.K., Tan, N.S. (2015) Angiopoietin-like 4 increases pulmonary tissue leakiness and damage during influenza pneumonia. Cell Reports. 10(5): 654-663 (IF: 10.0)

23. Li, L.（李亮，第一作者，通讯作者）,Foo, B.J.W., Kwok, K.W., Sakamoto, N., Mukae, H., Izumikawa, K., Mandard, S., Quenot, J.-P., Lagrost, L., Teh, W.K., Kohli, G.S., Zhu, P., Choi, H., Buist, M.L., Yang, L., He, F., Chow, V.T.K., Tan, N.S.. (2019) Antibody treatment against angiopoietin-like 4 (ANGPTL4) reduces pulmonary edema and injury in secondary pneumococcal pneumonia. mBio 10:e02469-18. (IF: 7.8)

24. Liang, L., Li, L.（李亮，通讯作者）, Rong, F.. (2020) Serum Creatinine as a Potential Biomarker for the Diagnosis of Tuberculous Pleural Effusion. American Journal of the Medical Sciences. (IF: 3.5)

25. Davient, B., Ng, J.P.Z., Xiao, Q., Li, L.（李亮，通讯作者）, and Yang, L..(2018) Comparative Transcriptomics Unravels Prodigiosin's Potential Cancer-Specific Activity Between Human Small Airway Epithelial Cells and Lung Adenocarcinoma Cells. Frontiers in Oncology. 8:573 (IF: 5.7)

26. Iyer, R.L., Li, L. （李亮，共一作者）, Wong, P.S., Sutejo, R., Tan, B.H., and Sugrue, R.J.. (2013) Lovastatin Treatment Mitigates the pro-Inflammatory Cytokine Response in Respiratory Syncytial Virus Infected Macrophage Cells. Antiviral Research 98(2): 332–43. (IF: 10.1)

27. Xu, K., Li, L.（李亮）, Han, Y., Karahan, H.E., Chow, V.T.K., Xu, C. (2017). Cold-chain-free Storable Hydrogel for Infant-friendly Oral Delivery of Amoxicillin for the Treatment of Pneumococcal Pneumonia. ACS Applied Materials & Interfaces.  9(22):18440-18449. (IF: 10.4).

28. Iyer, R.L., Li, L.（李亮）, Sutejo, R., Chen, H., Wong, P.S., Tan, B.H., and Sugrue, R.J.. (2013) A Systems-Based Approach to Analyse the Host Response in Murine Lung Macrophages Challenged with Respiratory Syncytial Virus. BMC Genomics 14(1): 190. (IF: 4.5)

29. Iyer, R.L., Li, L.（李亮）, Wong, P.S., Brown, G., Tan, B.H., and Sugrue, R.J.. (2013) Increased Hydroxymethylglutaryl Coenzyme A Reductase Activity during Respiratory Syncytial Virus Infection Mediates Actin Dependent Inter-Cellular Virus Transmission. Antiviral Research 100(1): 259–68. (IF: 10.1)

30. Tan, K.S., Yan, Y., Koh, W.L.H., Li, L.（李亮）, Choi, H., Tran, T., Sugrue, R., Wang, D.Y., and Chow, V.T.. (2018) Comparative Transcriptomic and Metagenomic Analyses of Influenza Virus-Infected Nasal Epithelial Cells From Multiple Individuals Reveal Specific Nasal-Initiated Signatures. Frontiers in Microbiology. 9:2685. (IF: 6.1)

31. Teo, Z.Q., Sng, M.K., Chan, J.S.K., Lim, M., Li, Y., Li, L.（李亮）, Phua, T., Lee, J., Tan, Z.W., Zhu, P., Tan, N.S.. (2017) Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial-mesenchymal transition by inducing 14-3-3γ expression. Oncogene. 2017.244 (IF: 8.8).

32. Wang, J.K., Luo, B., Guneta, V., Li, L.（李亮）, Foo, S.E.M., Dai, Y., Tan, T.T.Y., Tan, N.S., Choong, C., and Wong, M.T.C.. (2017) Supercritical carbon dioxide extracted extracellular matrix material from adipose tissue. Materials Science and Engineering: C. 75:349–358. (IF: 7.3).

33. Chan, J.S.K., Tan, M.J., Sng, M.K., Teo, Z., Phua, T., Choo, C.C., Li, L.（李亮）, Zhu, P., and Tan, N.S.. (2017) Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress. Cell Death Disease. 8:e2562. (IF: 9.7)